CORDIS Project
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This project aims to explore a newly identified liver-derived factor that suppresses hepcidin, a key regulator of iron homeostasis, to develop new treatments for various forms of anemia. The focus is on understanding its therapeutic potential through murine models.
Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population.
As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport.
The liver-derived peptide hepcidin is the master regulator of iron homeostasis.
During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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