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POLIRNA aims to create a versatile platform for delivering RNA therapies to various cell types, focusing on cardiac and muscle-related diseases. By developing polymer-lipid nanocarriers, the project seeks to improve the efficacy of RNA treatments.
Currently, RNA therapies are available on the clinics to treat liver diseases and as COVID-19 vaccines.
Hence, their therapeutic potential still remains largely unexploited for the treatment of other disorders, such as age-related, rare genetic and infectious diseases.
One key problem for effective preclinical research on new RNA therapies is the lack of safe, efficient and cell-specific delivery vehicles.
Gold-standard cationic lipid transfection reagents suffer from dose-dependent cytotoxicity…
POLITECNICO DI TORINO
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