CORDIS Project
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This project focuses on identifying novel inhibitors for the NLRP3 inflammasome, which is linked to chronic inflammatory diseases. By expanding the range of therapeutics targeting NLRP3, it aims to improve treatment options for patients suffering from related conditions.
Inflammasomes play a vital role in in protecting humans against pathogenic microorganisms, harmful substances and cell changes that could result in illness.
The NLRP3 inflammasome in particular attracts considerable interest because aberrant NLRP3 activation is a key pathogenic mechanism in many chronic inflammatory diseases.
Moreover, gain-of-function mutations in NLRP3 causes a periodic fever syndrome named cryopyrin-associated periodic syndrome (CAPS). MCC950/CRID3-based sulfonylurea compound…
UNIVERSITEIT GENT
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