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The SUPRAHEART project develops synthetic hydrogels for creating engineered heart tissues, enhancing reproducibility and scalability in cardiac models. This innovation aims to facilitate high-throughput testing for pharmaceuticals.
The SUPRAHEART proof-of-concept project aims to use our squaramide-based (SQ) filamentous double network hydrogels for assembly of engineered heart tissues (EHTs).
As the current dependency of EHTs on natural materials (e.g., collagen I, Matrigel) limits their large-scale application as cardiac models, their generation using a fully synthetic matrix will provide improved reproducibility, tunability and scalability, opening the door for their use as a high-throughput pharmaceutical testing platfo…
UNIVERSITEIT LEIDEN
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