CORDIS Project
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The T-BAP project focuses on developing therapeutic strategies for cancers and neurodevelopmental disorders associated with BAP1 mutations. By targeting specific components of the Polycomb Repressive Complex, the project aims to create new compounds that can restore normal cellular functions and improve patient outcome…
BAP1-related mutations are common genetic lesions of several cancers and neurodevelopmental disorders (NDDs).
BAP1 is a deubiquitinase that removes the repressive mono-ubiquitination at histone H2AK119 (H2Aub1) deposited by the Polycomb Repressive Complex 1 (PRC1) by associating with several regulatory subunits to form the Polycomb Repressive Deubiquitinase (PR-DUB) complex.BAP1 inactivating mutations represent a hallmark in Malignant Mesothelioma (MM) for which genetic models proved its oncogen…
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